Understanding Andropause: How a Genetic Biotype Test Can Help Men Age Better

When we hear “menopause,” we think of women — but men undergo their own hormonal transition: andropause, often dubbed “male menopause.” As testosterone declines with age, many men face fatigue, low libido, muscle loss, mood shifts, and metabolic challenges.

Yet, how and when these symptoms manifest varies widely. This is where a biotype genetic test for andropause becomes invaluable — predicting your likely symptoms and offering a personalized roadmap to maintain vitality through midlife and beyond.

The Science Behind Male Biotypes

Andropause isn’t simply about lower testosterone. It’s a complex interplay among hormones (testosterone, estradiol, DHEAS, SHBG), genetics, metabolism, and lifestyle stressors. Researchers now recognize key biomarkers — including testosterone/estradiol ratio — as signals of risk. 

A male biotype DNA test:

• Identifies your genetic tendencies toward symptom clusters (e.g. low energy, mood changes, muscle loss).

• Reveals disease predispositions (cardiovascular disease, insulin resistance, bone health).

• Guides which interventions — hormone therapy, nutrition, exercise — will align best with your biology.

Why Generic Tests Fall Short

Typical “male hormone tests” often measure total testosterone alone. While useful, they miss crucial context: free vs bound testosterone, estrogen conversion, gene variants impacting hormone processing. 

But these are still reactive snapshots. A true biotype test is predictive and holistic — offering forward-looking insight, not just current levels.

Real-Life Benefits Many Men Overlook

• Fewer months of guesswork in trying therapies

• Smarter lifestyle changes (tailored training, diet, sleep)

• Early detection and mitigation of disease risks

• Elevated confidence in treatment decisions

How the Andropause Biotype Test Works

1. Collect DNA 

2. Biomarker panels run in the lab (hormones, metabolic markers, etc.).

3. Integration with genetic variants produces your male biotype.

4. Receive results with recommended treatment, lifestyle, and monitoring strategies to be share with your provider or one of ours.

Notes from Research

• Testosterone declines about 1% annually after age 40, but only a fraction of men exhibit symptoms. 

• Andropause has been associated with bone density decline, increased visceral fat, mood shifts, and muscle atrophy. 

• The risk lies not only in low testosterone but in how your body handles hormonal balance — exactly what a biotype approach illuminates.

If you’re a man entering midlife and want to understand your hormonal trajectory, the andropause biotype genetic test from Rephase Health may be a powerful tool. Connect with us to learn more or request your kit.