What Does the Rephase DNA Test Actually Test For?

When people hear “hormone test,” they often assume we are measuring estrogen, progesterone, testosterone, or cortisol.

That is not what the Rephase Biotype DNA Test does.

Rephase is a DNA test. It analyzes inherited genetic variants that may influence how your body produces, transports, processes, signals, and responds to hormones. It also examines how hormone-related pathways interact with stress, sleep, metabolism, inflammation, mood, cognition, and other systems involved in the midlife transition.

In other words, bloodwork can show what is happening in your body at a particular moment. Rephase helps provide context for why your body may respond the way it does.

What does the Menopause DNA Test analyze?

The Rephase Menopause Biotype DNA Test analyzes 132 genetic variants across 19 curated hormone-health categories.

These categories include pathways related to:

• Hormone metabolism, signaling, regulation, transport, and clearance

• Estrogen receptor sensitivity

• Steroid and pituitary hormone function

• Menopause timing

• Reproductive tissue health

• Cortisol and biological stress response

• The interaction between stress and sex hormones

• Sleep and circadian rhythm

• Metabolism, appetite, and cardiometabolic function

• Inflammation and immune response

• Mood, emotional regulation, focus, and neurotransmitter activity

These systems do not operate independently. Stress can influence sleep. Sleep can affect appetite and energy. Hormone processing can interact with mood, inflammation, and metabolism.

That is why Rephase looks at biological pathways rather than presenting a disconnected list of genes.

What does the Andropause DNA Test analyze?

The Rephase Andropause Biotype DNA Test analyzes 177 genetic variants across 21 curated categories related to male hormone health and aging.

These include pathways involved in:

• Testosterone production, transport, metabolism, and sensitivity

• The availability of bioactive testosterone

• Stress and cortisol response

• Sleep, energy, and recovery

• Inflammation

• Weight and metabolic regulation

• Mood, focus, cognition, and motivation

• Cardiometabolic hormone function

The goal is to provide a more complete picture of the biological factors that may influence changes in energy, strength, libido, recovery, mood, focus, and body composition during midlife.

Is this the same as a hormone blood test?

No.

A hormone blood test measures what is circulating in your body when the sample is collected. Those levels can change with age, medication, stress, sleep, time of day, menstrual stage, and other factors.

Your DNA generally does not change.

That makes genetic information a durable starting point for understanding tendencies that may influence your experience over time. DNA testing and bloodwork can serve different purposes, and one does not replace the other.

Does the test diagnose menopause or andropause?

No. The Rephase test is not diagnostic.

It does not determine whether you are officially in menopause, diagnose a medical condition, guarantee that you will experience a particular symptom, or tell you that one treatment will work for you.

Your genes are not your destiny. Lifestyle, environment, medical history, current hormone levels, medications, and many other factors also influence how you feel.

The test is designed to help you understand your biological tendencies so you can make more informed wellness decisions and have more productive conversations with qualified healthcare professionals.

What will I learn from my report?

Your report is designed to help answer questions such as:

• Why might stress affect me differently now?

• Why has my sleep become less predictable?

• Why do hormonal shifts affect my mood, focus, or energy?

• How might my body process or respond to hormones?

• Which biological systems may be contributing to symptoms that appear together?

• Where might my body be more sensitive or resilient?

• What areas should I explore further with my healthcare provider?

Instead of giving you another collection of unexplained numbers, Rephase translates genetic information into a clearer story about how your biology may work as a system.

Why does Rephase analyze pathways instead of isolated genes?

Most biological functions involve multiple genes working together.

A single genetic variant rarely explains an entire symptom or health experience. Rephase uses the EndoDNA + BIOS platform to organize variants into interconnected pathways and translate that information into structured, understandable insights.

This approach helps connect the dots between hormones, stress, sleep, metabolism, inflammation, and cognitive or emotional changes.

How is the test completed?

The process begins with a simple at-home cheek swab. There is no blood draw or office appointment required for DNA collection.

Your sample is processed, your selected genetic variants are analyzed, and your personalized report is delivered through the secure Rephase portal. Results are generally available in approximately three to four weeks.

The simplest answer

So, what does the Rephase test test for?

It tests inherited genetic variants that may influence how your body experiences and responds to hormonal change.

It does not tell you your hormone levels today. It gives you a deeper view of the biological blueprint that has been with you all along.

Because when you understand your biology, you can stop relying entirely on guesswork and begin asking better questions about what comes next.

Explore the Menopause Biotype DNA Test

Explore the Andropause Biotype DNA Test

Rephase reports are educational and decision-support tools. They are not diagnostic tests and are not a substitute for medical evaluation, laboratory testing, or care from a qualified healthcare professional.